Novel borane reduction of ether-protected aromatic lactams.
نویسندگان
چکیده
Borane reduction of ether-protected aromatic lactams produces 1-alkyl-1,2,3,4-tetrahydroquinolines (5 and 6) in excellent yields. This reaction provides a novel one-pot tandem process for reduction of amide group and N-protected groups. Experimental results demonstrate that the reaction proceeds through two consecutive elimination and reductions via two C-O bond cleavages to form the foresaid products.
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ورودعنوان ژورنال:
- The Journal of organic chemistry
دوره 69 11 شماره
صفحات -
تاریخ انتشار 2004